Detalhe da pesquisa
1.
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia.
Nature
; 597(7877): 571-576, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34497422
2.
Structural basis of efficacy-driven ligand selectivity at GPCRs.
Nat Chem Biol
; 19(7): 805-814, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36782010
3.
Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor.
Mol Pharmacol
; 104(3): 92-104, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37348914
4.
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders.
Am J Physiol Gastrointest Liver Physiol
; 322(1): G66-G78, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34755545
5.
Crystal structure of the M5 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 116(51): 26001-26007, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31772027
6.
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 115(10): E2419-E2428, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453275
7.
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
Nat Chem Biol
; 19(4): 529, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36879062
8.
Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor.
Mol Pharmacol
; 95(3): 245-259, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30591538
9.
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.
Nature
; 503(7475): 295-9, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24121438
10.
Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature
; 504(7478): 101-6, 2013 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24256733
11.
Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.
Proc Natl Acad Sci U S A
; 113(38): E5675-84, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27601651
12.
Utility of an "Allosteric Site-Impaired" M2 Muscarinic Acetylcholine Receptor as a Novel Construct for Validating Mechanisms of Action of Synthetic and Putative Endogenous Allosteric Modulators.
Mol Pharmacol
; 94(5): 1298-1309, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30213802
13.
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
Mol Pharmacol
; 94(1): 770-783, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691279
14.
Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist.
Proc Natl Acad Sci U S A
; 111(12): 4614-9, 2014 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24619092
15.
Label-Free Kinetics: Exploiting Functional Hemi-Equilibrium to Derive Rate Constants for Muscarinic Receptor Antagonists.
Mol Pharmacol
; 88(4): 779-90, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26243731
16.
Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor.
J Biol Chem
; 289(34): 23817-37, 2014 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006252
17.
The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.
Annu Rev Pharmacol Toxicol
; 52: 153-78, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-21910627
18.
Endogenous allosteric modulators of G protein-coupled receptors.
J Pharmacol Exp Ther
; 353(2): 246-60, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25650376
19.
Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M1 muscarinic acetylcholine receptor.
Mol Pharmacol
; 84(3): 425-37, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23798605
20.
Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and ß-arrestin2-mediated pathways.
Biochem Pharmacol
; : 115988, 2023 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38159685